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Objective To study the risk environmental and psycho-social factors associated to prostate cancer (PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios (OR) and 95%confidence intervals (95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa (OR=0.39, 95%CI: 0.28-0.53; OR=0.59, 95% CI: 0.40-0.87, respectively). Family history of PCa (OR=7.16, 95% CI:2.01-25.49), history of prostate diseases (OR=2.28, 95%CI:1.53-3.41), alcohol consumption (OR=1.97, 95%CI:1.33-2.90), red meat consumption (OR=1.74, 95%CI:1.20-2.52), barbecued (OR=2.29, 95%CI:1.11-4.73) or fried (OR=2.35, 95%CI:1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks (OR=1.61, 95% CI: 1.00-2.59), marital separation (OR=1.94, 95%CI:1.29-2.91), self-contained suffering (OR=2.37, 95%CI:1.58-3.55), and high sensitivity to the personal comments (OR=1.73, 95%CI:1.18-2.54) were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population.