论文部分内容阅读
慢性乙肝病毒(HBV)感染是一个全球性的卫生问题,但HBV感染的具体机制仍不明确。目前研究证实其主要与病毒本身因素、宿主免疫因素和遗传因素相关。细胞因子在防御病毒感染中发挥重要作用,而肿瘤坏死因子-α(TNF-α)是宿主防御中的关键细胞因子,对固有免疫和适应性免疫系统有广泛影响。本文通过查阅相关文献,探索TNF-α启动子区域的4个位点(-308,-238,-863,-857)的基因多态性与乙肝感染的相关性。结果表明各个研究结论有所不同,但大多数结果支持TNF-α基因多态性影响人体对HBV的易感性。
Chronic hepatitis B virus (HBV) infection is a global health problem, but the exact mechanism of HBV infection remains unclear. The current study confirmed that the virus itself and the main factors, host immune factors and genetic factors. Cytokines play an important role in the defense against viral infections, and tumor necrosis factor-alpha (TNF-alpha) is a key cytokine in host defense with a wide range of effects on the innate and adaptive immune systems. In this paper, the relevant literature was explored to explore the relationship between the polymorphism of TNF-a promoter region (-308, -238, -863, -857) and HBV infection. The results show that the conclusions of the various studies are different, but most of the results support the TNF-α gene polymorphisms affect the human body’s susceptibility to HBV.