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目的 探讨慢性肾脏疾病患者外周血T淋巴细胞亚群的变化。方法 6 6例慢性肾脏疾病患者测定外周血T淋巴细胞亚群 (CD4、CD8、CD4 /CD8)、血清总蛋白 (TP)、血清白蛋白 (A1)、血清尿素氮 (BUN)、血清肌酐 (Scr)、血清甘油三酯 (TG)、血清胆固醇 (CHO)和 2 4h尿蛋白定量 (Pr/ 2 4h)。结果 :慢性肾脏疾病组CD4 (P <0 .0 5 )、CD4 /CD8、TP、A1(P <0 .0 0 1)均低于正常对照组 ,而CD8、BUN、Scr(P <0 .0 5 )、Pr/ 2 4h(P <0 .0 1)均高于正常对照组。CD8与Scr呈明显负相关 (P <0 .0 1)。而CD4、CD4 /CD8与Scr无明显相关性 (P>0 .0 5 ) ,CD4、CD8、CD4 /CD8与Pr/ 2 4h、TP、A1、BUN、TG、CHO无明显相关性 (P >0 .0 5 )。结论 慢性肾脏疾病患者存在T细胞功能紊乱 ,其与肾功能呈负相关 ,但与肾脏病患者尿蛋白排泄无明显相关性。
Objective To investigate the changes of peripheral blood T lymphocyte subsets in patients with chronic kidney disease. Methods Sixty patients with chronic kidney disease were enrolled in this study. T lymphocyte subsets (CD4, CD8, CD4 / CD8), serum total protein (TP), serum albumin (A1), serum urea nitrogen (BUN), serum creatinine Scr, serum triglyceride, serum cholesterol and 24 h proteinuria (Pr / 2 4 h). Results: The levels of CD4 (P <0.05), CD4 / CD8, TP and A1 in chronic kidney disease group were lower than those in normal control group, while CD8, BUN and Scr (P <0. 0 5), Pr / 2 4h (P <0 01) were higher than the normal control group. There was a clear negative correlation between CD8 and Scr (P <0.01). CD4, CD8, CD4 / CD8 and Pr / 2 4h, TP, A1, BUN, TG and CHO had no significant correlation (P> 0 .0 5). Conclusion There are T cell dysfunction in patients with chronic kidney disease, which is negatively correlated with renal function, but no significant correlation with urinary protein excretion in patients with kidney disease.