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Objective: The aim of the study was to observe the therapeutic effect of FOLFOX4 regimen plus Fufangchangtai decoction on postoperative colorectal cancers. Methods: Thirty postoperative colorectal cancer patients were allocated into control and experiment groups respectively. Patients in experiment group were given Fufangchangtai decoction combined with FOLFOX4 regimen. Patients in control group were given FOLFOX4 regimen alone. Efficacy was evaluated after 2 periods of treatment. Results: The improvement rate of symptoms were 86.6% in experiment group compared to 53.3% in control group. KPS was stable in experiment group, and decreased in control group. QOL was increased in experiment group, and stable in control group after the treatment. For impact of immunity parameters, there were enhancements of CD3+ and CD4+ in experiment group, while they did not change in control group. In experiment group, WBC reduction was slighter than that of control group. The differences were not remarkable in PLT reduction, alimentary response, and toxicity of liver and kidney and nervous system. Conclusion: The clinical observation showed that Fufangchangtai decoction plus FOLFOX4 regimen could effectively enhance KPS, improve the symptoms, the quality of life and the immunity state, and down-regulate the side effects. In conclusion, Fufangchangtai decoction can decrease the toxicity so as to increase the treatment effect.