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急性或慢性消化性溃疡是由损害因素和保护因素失衡所引起。消化性溃疡的愈合既可以通过减少损害因素,也可以通过加强粘膜保护因素。由于消化性溃疡是粘膜的特殊损伤,因而,坏死组织脱落的同时,刺激未分化表皮细胞生长的作用应被看作愈合过程的重要因素。文献报告,具有营养作用的表皮生长因子(epi-dermal growth factor,EGF)或胃泌素刺激粘膜生长,促进再上皮化和组织修复。硫糖铝、枸橼酸铋钾等药物可增加溃疡区域EGF的聚
Acute or chronic peptic ulcer disease is caused by the imbalance of damage and protection factors. Peptic ulcer healing can be both through the reduction of damaging factors, but also by strengthening mucosal protection factors. Since peptic ulcer is a specific mucosal injury, the role of necrotic tissue shedding while stimulating the growth of undifferentiated epidermal cells should be considered as an important factor in the healing process. It has been reported in the literature that vegetative epi-dermal growth factor (EGF) or gastrin stimulates mucosal growth and promotes re-epithelization and tissue repair. Sucralfate, bismuth potassium citrate and other drugs can increase the aggregation of EGF in the ulcer area