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目的讨论异甘草酸镁在自身免疫性肝炎中的疗效。方法选取2014年1月—2015年4月间本院住院治疗的自身免疫性肝炎患者共64例,将其以随机分组的形式均分为实验组及对照组,每组32例。实验组患者静脉滴注异甘草酸镁(250 ml葡萄糖注射液中含异甘草酸镁150 mg),1次/d;对照组患者静脉滴注复方甘草酸苷(250 ml葡萄糖注射液中含复方甘草酸苷150 mg),1次/d。两组患者均用药1个月,观察对比两组患者病情缓解情况,计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果实验组腹胀、恶心、乏力、纳差等反应减轻率(93.7%、90.6%、90.6%、90.6%)均优于对照组(65.5%、68.7%、65.6%、68.7%),差异均有统计学意义(均P<0.05);两组生化指标下降程度对比,实验组较对照组优势明显,差异均有统计学意义(均P<0.05)。实验组总有效率(93.7%)明显优于对照组(62.5%),对比差异有统计学意义(P<0.05)。实验组仅出现不良反应发生率(6.2%)明显少于对照组(37.5%),对比差异有统计学意义(P<0.05)。结论在自身免疫性肝炎的临床治疗中,异甘草酸镁效果显著,且优于复方甘草酸苷,值得推广使用。
Objective To investigate the efficacy of magnesium isoglycyrrhizinate in autoimmune hepatitis. Methods A total of 64 patients with autoimmune hepatitis hospitalized in our hospital from January 2014 to April 2015 were randomly divided into experimental group and control group, with 32 cases in each group. Patients in the experimental group were given intravenous infusion of compound glycyrrhizin (250 mg glucose injection containing 150 mg glycyrrhizin in 250 ml glucose injection) , 1 time / d. Two groups of patients were treated for 1 month, observed and compared the two groups of patients to alleviate the situation, measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results In the experimental group, the rate of adverse reactions such as abdominal distension, nausea, fatigue and anorexia was significantly higher than that of the control group (93.5%, 68.6%, 90.6%, 90.6%, 65.5%, 68.7%, 65.6%, 68.7% (All P <0.05). Compared with the control group, there were significant differences in the biochemical indexes between the two groups (all P <0.05). The total effective rate (93.7%) in the experimental group was significantly better than that in the control group (62.5%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in experimental group (6.2%) was significantly less than that in control group (37.5%), the difference was statistically significant (P <0.05). Conclusion In the clinical treatment of autoimmune hepatitis, magnesium isoglycyrrhizinate has a significant effect and is superior to compound glycyrrhizin, which is worth popularizing.