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临床使用利尿剂治疗高血压常引起高尿酸血症。曲呫司(Traxanox)是一种具有促尿酸尿作用的新利尿剂,初步研究结果表明,本品能使正常血压健康人产生利尿和促尿酸尿作用。作者研究了本品对高血压患者血压和血清尿酸水平的作用。受试者为15例轻至中度高血压病人,收缩压≥150或舒张压≥90mmHg,已预先排除严重肝病或肾病患者。受试者参试前2周内未用过任何抗高血压药。试验采取单盲交叉方案,给受试者口服本品90mg或安慰剂,一日3次,共4周。对疗效不显者,从服药的第3周起将本品剂量增至120mg。定期测量
Clinical use of diuretic treatment of hypertension often cause hyperuricemia. Traxanox (Traxanox) is a new diuretic with uricosuric effect. The preliminary results show that this product can make diuretic and uricuric effects in normal blood pressure healthy people. The authors studied the effect of this product on blood pressure and serum uric acid levels in patients with essential hypertension. Subjects were 15 patients with mild to moderate hypertension, systolic blood pressure ≥ 150 or diastolic blood pressure ≥ 90mmHg, have been excluded in patients with severe liver disease or kidney disease. Subjects did not use any antihypertensive medication within 2 weeks prior to the test. The test to be single blind crossover program, the subjects oral administration of this product 90mg or placebo, three times a day for a total of 4 weeks. The curative effect is not significant, from the first 3 weeks of taking the dose will be increased to 120mg. Regular measurement