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自从发现乙型肝炎抗原以来,近十年来病毒性肝炎的研究进展十分迅速。虽然有关肝炎病毒的分离还未完全解决,但对甲、乙二型肝炎病毒抗原颗粒的超微结构、理化特性、抗原组成、动物模型和检测方法等方面,已取得了显著的成就。甲型肝炎病毒(HAV)在狨猴和黑猩猩体内的接种和传代已经成功,从急性期病人粪内已分离到一种病毒或抗原颗粒,并建立了对HAV特异性抗体的测定方法。人们对乙型肝炎病毒(HBV)的研究更为深入,已知有:HB_sAg、HB_cAg和
Since the discovery of hepatitis B antigens, the research on viral hepatitis has progressed rapidly in recent ten years. Although the isolation of hepatitis B virus has not been completely resolved, remarkable achievements have been made in the ultrastructure, physicochemical properties, antigen composition, animal models and detection methods of the hepatitis A and B antigen particles. Vaccination and passage of Hepatitis A virus (HAV) in marmosets and chimpanzees has been successful. A virus or antigen particle has been isolated from the faeces of the acute phase and a method for the determination of HAV-specific antibodies has been established. The research on Hepatitis B virus (HBV) has been further studied. Known as: HB_sAg, HB_cAg and