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目的探讨Ⅱ型糖尿病并发多脏器病变时，及应用胎胸腺素（ＦｅｔａｌＴｈｙｍｏｓｉｎ，ＦＴ）治疗前后其免疫功能的变化。方法采用ＡＰＡＡＰ桥联酶标法测定外周血Ｔ细胞亚群。应用Ｈａｎｋｓ液制做胸腺素混悬液。随访观察不同时期Ⅱ型糖尿病并发慢性多脏器病变患者外周血Ｔ细胞亚群及心、肾、脑功能的变化。结果治疗前，无明显脏器病变的Ⅱ型糖尿病组与正常对照组之间Ｔ细胞亚群无显著差异（Ｐ＞０．０５）；两组心、肾、脑等脏器病变者Ｔ细胞亚群明显低于对照组（Ｐ＜０．０１）；治疗后，ＦＴ组外周血Ｔ细胞亚群上升，６０天峰值达：ＣＤ２８４．１±１．６％，ＣＤ４／ＣＤ８２．５±１．３，与对照组相比Ｔ细胞亚群升高显著（Ｐ＜０．０１），同时心、肾、脑功能亦有明显恢复。结论Ⅱ型糖尿病并发慢性多脏器病变时，免疫功能明显低下，胸腺素具有免疫兴奋作用，并有助于改善心、肾、脑功能。
Objective To investigate the changes of immune function in type 2 diabetic patients with multiple organ disease and before and after treatment with Fetal Thymosin (FT). Methods The peripheral blood T lymphocyte subsets were detected by APAAP in situ hybridization. Apply Hanks solution to make thymosin suspension. The changes of T lymphocyte subsets and the function of heart, kidney and brain in peripheral blood of patients with type Ⅱ diabetes complicated with chronic multiple organ disease at different stages were observed. Results Before treatment, there was no significant difference in T cell subsets between type 2 diabetic patients and normal control subjects (P> 0.05). There were no significant differences in T cell subsets between the two groups (P <0.01). After treatment, the T lymphocyte subsets of peripheral blood in FT group increased at 60 days peak: CD284.1 ± 1.6% and CD4 / CD82.5 ± 1.3 Compared with the control group, T lymphocyte subsets increased significantly (P <0.01), meanwhile heart, kidney and brain function also recovered obviously. Conclusion In type Ⅱ diabetic patients with chronic multiple organ disease, immune function is obviously low. Thymosin has the function of immune excitement and helps to improve heart, kidney and brain function.