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目的:探讨诱骗受体(Decoy receptor 3,Dc R3)蛋白在人食管鳞状细胞癌中的表达和临床意义。方法:通过免疫组化的方法,在人食管鳞状细胞癌组织和正常食管粘膜组织各112例中检测Dc R3蛋白的表达差异,并分析Dc R3蛋白表达与食管鳞状细胞癌临床病理学特征间的相关性。结果:在组织标本中检测发现,Dc R3蛋白在食管鳞状细胞癌组织中的阳性表达为72.3%,在正常食管粘膜组织中的阳性表达为25.9%。卡方检验分析表明,Dc R3蛋白在食管鳞状细胞癌组织中的阳性表达与食管鳞状细胞癌的临床分级(P=0.002)、淋巴结转移(P<0.001)、组织学分级(P=0.01)具有显著相关性,而与患者的年龄(P=0.673)、性别(P=0.378)、抽烟史(P=0.392)、饮酒史(P=0.093)等均无关。Spearman相关性分析检测发现,Dc R3蛋白高表达与高临床分级(r=-0.213,P=0.024)、高组织学分级(r=-0.285,P=0.002)、淋巴结转移(r=-0.568,<0.001)呈正相关,而与食管鳞状细胞癌患者的年龄、性别、吸烟史、饮酒史等均无相关性(P>0.05)。结论:Dc R3蛋白在食管鳞状细胞癌组织中表达更高,且与食管鳞状细胞癌疾病的进展、转移呈正相关。Dc R3蛋白表达可用来检测食管鳞状细胞癌疾病严重程度。
Objective: To investigate the expression and clinical significance of Decoy receptor 3 (Dc R3) protein in human esophageal squamous cell carcinoma. Methods: The expression of DcR3 protein was detected by immunohistochemistry in 112 human esophageal squamous cell carcinoma and normal esophageal mucosa, and the relationship between DcR3 protein expression and clinicopathological characteristics of esophageal squamous cell carcinoma Relevance between. Results: The positive expression of DcR3 protein in esophageal squamous cell carcinoma was 72.3% in tissue samples, and 25.9% in normal esophageal mucosa. Chi-square test analysis showed that the positive expression of Dc R3 protein in esophageal squamous cell carcinoma was significantly associated with clinical grade (P = 0.002), lymph node metastasis (P <0.001), histological grade (P = 0.01 ) Had significant correlation with age (P = 0.673), sex (P = 0.378), smoking history (P = 0.392), alcohol consumption history (P = 0.093) and so on. Spearman correlation analysis showed that the expression of DcR3 protein was associated with high clinical grade (r = -0.213, P = 0.024), high histological grade (r = -0.285, P = 0.002), lymph node metastasis (r = -0.568, <0.001), but not with the age, sex, smoking history and drinking history of patients with esophageal squamous cell carcinoma (P> 0.05). Conclusion: The Dc R3 protein is highly expressed in esophageal squamous cell carcinoma and is positively correlated with the progression and metastasis of esophageal squamous cell carcinoma. Dc R3 protein expression can be used to detect the severity of esophageal squamous cell carcinoma disease.