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目的探讨非小细胞肺癌血清中ILK和MMP-9的表达在肿瘤侵袭转移过程中的作用机制。方法采用双抗体夹心ABC-ELISA法测定。结果 (1)肺癌血清中ILK和MMP-9的含量明显高于对照组,且两者间存在正相关性。(2)Ⅲ+Ⅳ期肺癌血清ILK、MMP-9显著高于Ⅰ+Ⅱ期,有淋巴结转移者血清ILK-1和MMP-9含量较无淋巴结转移者显著增高。结论 ILK-1、MMP-9可作为了解肺癌侵袭和转移辅助诊断的指标。
Objective To investigate the role of ILK and MMP-9 in the serum of non-small cell lung cancer (NSCLC) in the process of tumor invasion and metastasis. Methods Double antibody sandwich ABC-ELISA assay. Results (1) The levels of ILK and MMP-9 in lung cancer serum were significantly higher than those in control group, and there was a positive correlation between them. (2) Serum levels of ILK and MMP-9 in Ⅲ + Ⅳ stage lung cancer patients were significantly higher than those in stage Ⅰ + Ⅱ stage. Serum levels of ILK-1 and MMP-9 in patients with stage Ⅲ + Ⅳ disease were significantly higher than those without lymph node metastasis. Conclusion ILK-1, MMP-9 can be used as an index to help diagnose the invasion and metastasis of lung cancer.