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用双抗夹心ＥＬＩＳＡ方法检测３４例成人急性白血病患者脑脊液中可溶性白细胞介素２受体（ｓＩＬ－２Ｒ），７例中枢神经系统白血病（ＣＮＳＬ）初诊或复发患者脑脊液中ｓＩＬ－２Ｒ水平较７例ＣＮＳＬ已缓解及２０例无ＣＮＳＬ急性白血病患者明显升高（Ｐ＜０．０５）。ＣＮＳＬ已缓解者脑脊液中ｓＩＬ－２Ｒ接近非白血病对照水平（Ｐ＞０．０５）。脑脊液中ｓＩＬ－２Ｒ变化与胞脊液白细胞计数、蛋白、糖、氯化物等指标无明显统计学意义，但与ＣＮＳＬ患者病理细胞有无、化疗疗效相关。脑脊液中ｓＩＬ－２Ｒ水平不受其血清水平影响。提示监测急性白血病患者脑脊液中ｓＩＬ－２Ｒ水平有助于ＣＮＳＬ的诊断及疗效评定。
The levels of soluble interleukin 2 receptor (sIL-2R) in cerebrospinal fluid (CSF) of 34 adult patients with acute leukemia and sIL-2R levels in cerebrospinal fluid of 7 patients with CNSL were compared with 7 patients CNSL has been alleviated and 20 patients without CNSL acute leukemia was significantly higher (P <0.05). SIL-2R in cerebrospinal fluid of CNSL-treated group was close to that of non-leukemia control group (P> 0.05). The changes of sIL-2R in cerebrospinal fluid were not associated with the counts of CSF, protein, glucose and chloride in the CSF, but correlated with the curative effect of pathological cells in CNSL patients. CSF levels of sIL-2R are not affected by their serum levels. It is suggested that monitoring sIL-2R levels in cerebrospinal fluid of patients with acute leukemia contributes to the diagnosis and evaluation of CNSL.