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卵子发育是复杂的生理过程。卵子发育过程中染色质结构发生显著的变化,经历由非环绕核仁型向环绕核仁型卵子的转变,并伴随基因转录活性的改变。表观遗传修饰在染色质重构和基因转录调节中发挥重要作用,主要通过组蛋白乙酰化/去乙酰化的平衡实现。颗粒细胞和卵细胞胞质的积聚可能为卵子染色质重构和转录抑制提供初始信号。对卵子发育过程中染色质结构和基因转录调控的表观遗传学变化综述。
Oocyte development is a complex physiological process. The chromatin structure changes evolu- tively during egg development, undergoes a transition from a non-circumscribed nucleolar type to a nucleolar-type ovum, accompanied by a change in gene transcriptional activity. Epigenetic modifications play an important role in chromatin remodeling and gene transcription regulation, mainly through the balance of histone acetylation / deacetylation. The accumulation of granulosa cells and oocyte cytoplasm may provide initial signals for egg chromatin remodeling and transcriptional repression. Epigenetic Changes in Chromatin Structure and Gene Transcription during Oocyte Development.