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目的探讨妊娠晚期肝损害的病因构成。方法对2010-2012年南通地区妊娠晚期住院孕妇的资料进行整理,统计、分析肝功能损害的病例数及病因构成。结果 20 478例妊娠晚期孕妇中,肝损害643例,发病率为3.14%。其中,妊娠期肝内胆汁淤积症(ICP)184例(28.62%),妊娠期高血压疾病83例(12.91%),非酒精性脂肪肝(NAFLD)66例(10.26%),妊娠期病毒性肝炎(VHP)50例(7.78%),妊娠期急性脂肪肝(AFLP)9例(1.40%),感染中毒性肝损害7例(1.09%),胆系疾病5例(0.78%),乙肝后肝硬化3例(0.47%),HELLP综合征3例(0.47%),病因不明233例(36.22%)。结论妊娠晚期肝损害中最常见的病因是ICP、妊娠期高血压疾病、NAFLD及VHP。NAFLD的发病率越来越高,应引起足够的重视。
Objective To explore the causes of liver damage in late pregnancy. Methods The data of pregnant women in hospital during the third trimester of pregnancy from 2010 to 2012 in Nantong area were collected and analyzed. The number of cases of liver dysfunction and the cause of the etiology were analyzed. Results 20 478 pregnant women in the third trimester of pregnancy, liver damage 643 cases, the incidence was 3.14%. Among them, 184 cases (28.62%) of pregnancy induced intrahepatic cholestasis (ICP), 83 cases of hypertensive disorder complicating pregnancy (12.91%), 66 cases of non-alcoholic fatty liver disease (NAFLD) 50 cases of hepatitis (VHP) (7.78%), 9 cases of acute fatty liver during pregnancy (1.40%), 7 cases of toxic liver damage (1.09%), 5 cases of biliary disease (0.78% Liver cirrhosis in 3 cases (0.47%), HELLP syndrome in 3 cases (0.47%), etiology of unknown 233 cases (36.22%). Conclusions The most common causes of liver damage in late pregnancy are ICP, gestational hypertension, NAFLD and VHP. The incidence of NAFLD is getting higher and higher, should cause enough attention.