急性胰腺炎细胞因子的动态变化及其意义

• 作 者: 陆晓青 冉江华 郭群 张家骅 孙辉
• 机 构: 昆明医学院第二附属医院肝胆研究室
• 出 处: 中国普通外科杂志
• 发表日期: 1999年03期
• 关键词: 细胞因子 肿瘤坏死因子 白细胞介素 病程发展 水肿型 临床症状 组织损伤 免疫干预 实验分组 多器官衰竭

目的探讨细胞因子在急性胰腺炎病程发展中的作用。方法应用ＥＬＩＳＡ法检测２８例急性胰腺炎病人血液中肿瘤坏死因子（ＴＮＦα），可溶性白介素２受体（ＳＩＬ２Ｒ），白介素６（ＩＬ６）。结果急性胰腺炎病人血液中ＴＮＦα，ＳＩＬ２Ｒ，ＩＬ６含量明显增高（与正常对照组相比Ｐ＜０．０５），并与临床症状的变化相一致。结论细胞因子参与了急性胰腺炎病程发展的过程，并且是组织损伤的重要因素。

Objective To investigate the role of cytokines in the development of acute pancreatitis. Methods Tumor necrosis factor (TNFα), soluble interleukin 2 receptor (SIL2R) and interleukin6 (IL6) were measured in 28 patients with acute pancreatitis by ELISA method. Results The levels of TNFα, SIL2R and IL6 in the blood of patients with acute pancreatitis were significantly increased (P <0.05 compared with the normal control group) and were consistent with the changes of clinical symptoms. Conclusion Cytokines are involved in the process of acute pancreatitis development and are important factors of tissue injury.