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目的 :观察持续吸入两种不同浓度NO对豚鼠气道阻力的影响。方法 :健康雄性豚鼠 36只 ,随机分为对照组、异丙肾上腺素组、2 0× 10 -6和 6 0× 10 -6NO吸入组。用肺功能检测微机处理系统记录各组的基础呼气阻力 (RE)和动态顺应性 (Cdyn) ,以及每次静脉给予组胺后RE 和Cdyn的改变。结果 :①静脉给予 80、12 0及 16 0 μg/kg组胺后 ,2 0× 10 -6及 6 0× 10 -6NO吸入组的RE 值明显低于对照组 ;给予较低浓度组胺 (2 0、40 μg/kg)后 ,吸入NO两浓度组的RE 值也低于对照组 ,但无显著差异。②给予 80、12 0、16 0 μg/kg组胺后 ,NO吸入组的Cdyn明显高于对照组 ;在较低浓度组胺激发后 ,吸入NO两组的Cdyn改变与对照相比亦无明显差异。③在给予 80、12 0及 16 0 μg/kg组胺后 ,吸入NO两组的RE 值显著高于异丙肾组 ,而Cdyn值则显著低于异丙肾组。④各个阶段吸入NO两浓度组的RE 及Cdyn值均无明显差别。结论 :在高浓度组胺激发后 ,吸入NO对组胺的拮抗作用较为显著 ,但与异丙肾相比较弱 ,2 0× 10 -6和6 0× 10 -6NO的拮抗作用没有强度上的差别。
Objective: To observe the effects of continuous inhalation of two different concentrations of NO on airway resistance in guinea pigs. Methods: Thirty - six healthy male guinea pigs were randomly divided into control group, isoproterenol group, 20 × 10 -6 and 60 × 10 -6 NO inhalation groups. Pulmonary function tests were performed on the computerized treatment system to record the basal expiratory resistance (RE) and dynamic compliance (Cdyn) of each group, as well as changes in RE and Cdyn after each intravenous administration of histamine. Results: (1) After intravenous administration of 80, 120 and 160 μg / kg histamine, RE values of 20 × 10 -6 and 60 × 10 -6 NO inhalation groups were significantly lower than those of the control group; administration of histamine at a lower concentration 2 0, 40 μg / kg), the RE values of inhaled NO concentration group were also lower than those of the control group, but no significant difference was found. ② After 80, 120, 160 μg / kg histamine administration, the level of Cdyn in NO inhalation group was significantly higher than that in control group; after the low concentration of histamine challenge, the Cdyn uptake of NO group had no significant change compared with control group difference. ③ After administration of 80, 120 and 160 μg / kg histamine, the RE values of NO inhalation group were significantly higher than that of isoproterenol group, while the Cdyn value was significantly lower than that of isoproterenol group. ④ There was no significant difference in RE and Cdyn values between two groups inhaled NO at each stage. CONCLUSION: The antagonism of inhaled NO to histamine is obvious after high concentration of histamine challenge, but it is weaker than that of isoproterenol. The antagonistic effect of NO at 20 × 10 -6 and 6 × 10 -6 NO is not significant difference.