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强的松龙片剂和强的松片剂一样在临床上存在不等效问题。国外药典规定出厂前必须作溶解试验,要求在规定的溶解仪中20分钟内溶出率不得少于标示量的60%。本研究所采用的制剂的含量和崩解度都符合药典规定。先通过体外溶解试验选出溶解最快(A)、最慢(C)者以及滴丸(B)作为体内试验的样品。体内试验是选用8个健康的志愿者对三个样品进行交叉试验。试验时口服片剂2片(10mg)、滴丸4粒
Prednisone tablets and prednisone tablets in the clinical presence of inequalities. Foreign Pharmacopoeia provisions must be dissolved before leaving the factory test, requiring the dissolution of the instrument within 20 minutes dissolution rate shall not be less than 60% of the labeled amount. The content and disintegration of the preparations used in this study are in line with the provisions of the Pharmacopoeia. The most rapidly dissolving (A), slowest (C), and dropping pill (B) were selected as in vivo samples by in vitro dissolution test. In vivo experiments were performed on eight samples from eight healthy volunteers. Test oral tablet 2 (10mg), dropping pills 4