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抗中性粒细胞胞浆抗体(antineutrophil cytoplasmic antibody,ANCA)是针对中性粒细胞颗粒成分和单核细胞溶酶体的自身抗体。根据间接免疫荧光的着染部位不同分为胞浆型(c-ANCA)和核周型(pANCA)。血清中的ANCA不仅与系统性小血管炎有明显相关,而且与自身免疫性疾病也有一定的关联性[1]。本文就血清ANCA检测在系统性红斑狼疮(systemic lupus erythematosus,SLE)、类风湿关节炎(rheumatoid arthritis,RA)、原发性干燥综合征
Antineutrophil cytoplasmic antibody (ANCA) is an autoantibody directed against neutrophil granule components and monocytes lysosomes. According to the indirect immunofluorescence staining of the different parts into cytoplasm (c-ANCA) and perinuclear (pANCA). Serum ANCA is not only significantly associated with systemic microangiopathy, but also with autoimmune diseases have some relevance [1]. In this paper, serum ANCA detection in systemic lupus erythematosus (SLE), rheumatoid arthritis (rheumatoid arthritis, rheumatoid arthritis, rheumatoid arthritis (RA,