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糖皮质激素(以下称激素)对许多疾病确有良好的治疗作用,但是超过生理剂量的激素将对机体产生不良的影响,在治疗过程中可出现一些副作用和并发症,尤其在基层,往往因滥用激素常造成严重后果。现结合临床病例,就激素应用中出现的某些副作用和并发症及其防治介绍如下,以供参考。一、类柯兴氏综合征【例1】女患者,25岁,农民。因精神失常4天于1980年4月15日入院.诊断病毒性脑炎。给予病毒灵、氯霉素、维生素制剂、镇静剂、神经细胞活化剂如 ATP、辅酶 A,同时使用激素,按中程疗法给药,开始时地塞米松10毫克/日静滴,一周后改用强的松30毫克/日口服,以后每周递减5毫克,用至第6周激素总量折合强的松1,100毫克时,精神神经症状消失,但出现典型的“满月脸”、“水牛背”、向心性肥胖等。停用激素,用中药内服,住院59天出院。随访
Glucocorticoids (hereinafter referred to as hormones) do have a good therapeutic effect in many diseases, but hormones in excess of the physiological dose will have adverse effects on the body, and some side effects and complications may occur during the treatment, especially at the grassroots level, often due to Abuse of hormones often has serious consequences. Now combined with clinical cases, some of the side effects and complications of hormone therapy and its prevention and treatment are described below, for reference. First, the class Cushing’s syndrome [Example 1] Female patients, 25 years old, peasants. Four days due to mental disorders admitted to hospital on April 15, 1980. Diagnosis of viral encephalitis. Give Viral spirit, chloramphenicol, vitamin preparations, sedatives, nerve cell activators such as ATP, coenzyme A, at the same time the use of hormones, according to medium-range therapy, beginning dexamethasone 10 mg / day intravenous infusion, Prednisone 30 mg / day orally, then decreased 5 mg per week, with the first 6 weeks hormone equivalent to prednisone 1,100 mg, the neurological symptoms disappeared, but there are typical “full moon face”, “buffalo back” , Concentric obesity and so on. Stop using hormones, with Chinese medicine orally, hospitalized 59 days discharged. Follow-up