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目的：探讨选择性动脉药物灌注在治疗直肠癌中的临床疗效和不良反应，方法：对４８例直肠癌行选择性肠系膜下动脉或／和骼内动脉灌注化疗。结果：①ＣＲ０％，ＰＲ３５４％，ＭＲ５２１％，有效率３５４％；②４０例行２期手术，术中见病灶周围明显纤维化，术后病理证实病灶周围炎性细胞浸润和纤维组织增生。③骨髓抑制、胃肠道反应明显。④并发症：２例发生完全肠梗阻，１例左半结肠坏死。结论：于直肠癌手术切除前先行选择性动脉药物灌注化疗，可提高手术切除率，降低术后局部复发和远处转移可能，该方法有一定的毒副反应和发生肠梗阻、肠坏死的潜在危险
Objective: To investigate the clinical efficacy and adverse reactions of selective arterial infusion in the treatment of rectal cancer. Methods: Selective inferior mesenteric artery or/and intra-arterial infusion chemotherapy was performed on 48 cases of rectal cancer. Results: 1 CR0%, PR35 4%, MR52 1%, effective rate of 35 4%; 240 cases underwent two-stage operation, the lesions around the lesion showed significant fibrosis, pathologically confirmed lesions around the inflammatory cell infiltration and fiber Tissue hyperplasia. 3 bone marrow suppression, gastrointestinal reactions significantly. 4 complications: 2 cases of complete intestinal obstruction, 1 case of left colon necrosis. Conclusion: Selective arterial infusion chemotherapy before rectal cancer resection can improve the resection rate and reduce the possibility of local recurrence and distant metastasis. This method has certain toxicity and potential for intestinal obstruction and intestinal necrosis. Danger