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目的:探讨老年Ⅰ期非小细胞肺癌(NSCLC)体部立体定向放疗(SBRT)的近期疗效及安全性。方法:回顾性分析经SBRT治疗的5例老年Ⅰ期周围性NSCLC患者,给予肿瘤病灶50 Gy/5 F,95%以上剂量线覆盖PTV50的靶区范围,分别于放疗结束后1个月和3个月复查胸部CT,观察近期疗效,并评价急性放疗反应。结果:放疗结束后1个月复查评价疗效,1例完全缓解(CR),4例部分缓解(PR),放疗结束后3个月评价疗效,4例达CR,1例PR,有效率达100%,生活质量也明显改善,没有发现可评价的急性放射性肺炎表现及骨髓抑制。5例患者中皮肤反应均为1级。结论:SBRT治疗老年Ⅰ期NSCLC是一种安全、有效的治疗手段。
Objective: To investigate the short-term efficacy and safety of stereotactic body radiotherapy (SBRT) in elderly patients with stage I non-small cell lung cancer (NSCLC). METHODS: Five patients with stage I peripheral NSCLC treated with SBRT were retrospectively analyzed. The tumor lesions were given 50 Gy/5 F. Over 95% of the dose lines covered the target range of PTV50, 1 month and 3 months after the end of radiotherapy, respectively. Chest CT was reviewed monthly to observe the short-term efficacy and to evaluate the response to acute radiotherapy. Results: One month after the end of radiotherapy, the efficacy was reviewed, 1 case of complete remission (CR), 4 cases of partial remission (PR), 3 months after radiotherapy, efficacy was evaluated, 4 cases were CR, 1 case was PR, and the effective rate was 100. %, Quality of life has also improved significantly, and no evaluable acute radiation pneumonitis and myelosuppression have been found. In 5 patients, the skin reactions were all grade 1. Conclusion: SBRT is a safe and effective treatment for elderly patients with stage I NSCLC.