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目的:探讨重度子痫前期(s-PE)伴发代谢综合征(MS)的临床特点。方法:2006年12月至2012年4月江苏省人民医院妇幼分院共收治s-PE患者246例,其中伴MS者80例(代谢组),未伴MS者166例(对照组)。比较两组患者的孕期体重指数(BMI),发病孕周、终止妊娠孕周、临床体征、生化指标、并发症及母婴结局。结果:代谢组患者的BMI、水肿、胸水、腹水、脂肪肝发生率、血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、尿酸(UA)、24h尿蛋白定量、肌酐(Cr)、总胆固醇(TC)、三酰甘油(TG)、空腹血糖(FBG)水平、早产及新生儿窒息发生率均显著高于对照组(P<0.05);而血清高密度脂蛋白(HDL)显著低于对照组(P<0.05)。结论:s-PE伴发MS者脂肪肝发生率较高,糖脂代谢异常较重,易发生肝肾功能损伤,且早产及新生儿窒息发生率高。
Objective: To investigate the clinical features of severe preeclampsia (s-PE) associated metabolic syndrome (MS). Methods: From December 2006 to April 2012, 246 cases of s-PE patients were treated in Jiangsu Women’s and Children’s Hospital. Among them, 80 patients with metabolic syndrome (MS) and 166 without MS (control group). The body mass index (BMI), gestational weeks of pregnancy, gestational weeks of pregnancy termination, clinical signs, biochemical indexes, complications and maternal-infant outcomes were compared between the two groups. Results: The metabolic rate of BMI, edema, pleural effusion, ascites, fatty liver, serum ALT, AST, LDH, UA, , Creatinine (Cr), total cholesterol (TC), triglyceride (TG), fasting blood glucose (FBG) and the incidence of preterm birth and neonatal asphyxia were significantly higher than those of the control group (P <0.05) Protein (HDL) was significantly lower than the control group (P <0.05). Conclusion: The incidence of fatty liver in s-PE patients with MS is high, and the abnormal glucose and lipid metabolism is serious. It is easy to cause liver-kidney dysfunction, and the incidence of premature birth and neonatal asphyxia is high.