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由于胰岛素的应用,使糖尿病人因酮症酸中毒的病死率已显著地下降,但是长期以来,对治疗糖尿病酮症酸中毒时在胰岛素的用量和用法上,一直没有一个公认合理的治疗方案。过去所沿用的大剂量胰岛素间断注射治疗,虽然取得了肯定的疗效,但是对于是否必须用如此大的剂量(如每隔几小时注射100～200u.),也缺少必要的生理和药理学的根据,而且因用大剂量往往带来迟发性低血糖、低血钾、高乳酸血症、低磷血症、低镁血症和渗透压失衡症等危险。进入60年代以后,由于胰岛素放射免疫测定技术的应用和对胰岛素受体研究的进展,不仅推动了对胰岛素基础理
The mortality of diabetic patients due to ketoacidosis has dropped significantly due to the use of insulin. However, there has been no accepted and reasonable treatment regimen for insulin dosage and usage in the treatment of diabetic ketoacidosis for a long time. In the past, high-dose intermittent insulin injections, although affirmative, were still lacking in the necessary physiological and pharmacological basis for the need for such large doses (eg, 100 to 200 u every few hours) , But also due to the use of large doses often bring the symptoms of delayed hypoglycemia, hypokalemia, lactic acidosis, hypophosphatemia, hypomagnesemia and osmotic pressure imbalance and other risks. Into 60 years later, due to the application of insulin radioimmunoassay technology and progress on insulin receptor research, not only to promote the basic principles of insulin