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目的:通过测定毛细支气管炎患儿的血清人软骨糖蛋白以及潮气量、达峰时间比和达峰容积比,以探讨各指标在毛细支气管炎中的意义。方法:检测毛细支气管炎患儿85例(轻度组40例、重度组45例)、普通肺炎患儿44例、对照组47例患儿的血清人软骨糖蛋白浓度,测定毛细支气管炎组与普通肺炎组患儿潮气量、达峰时间比和达峰容积比,并进行统计学分析。结果:血清人软骨糖蛋白浓度毛细支气管炎组高于肺炎组及对照组(P<0.05)。轻度毛细支气管炎组、重度毛细支气管炎组及普通肺炎组3组潮气量差异无统计学意义(F=0.90,P=0.408)。达峰时间比3组间比较有统计学意义(H=74.844,P<0.001);重度毛细支气管炎组低于轻度毛细支气管炎组(χ~2=8.78,P<0.05),轻度毛细支气管炎组低于普通肺炎组(χ~2=27.50,P<0.05)。达峰容积比3组间比较有统计学意义(H=76.392,P<0.001);重度毛细支气管炎组低于轻度毛细支气管炎组(χ~2=6.80,P<0.05),轻度毛细支气管炎组低于普通肺炎组(χ~2=32.70,P<0.05)。相关性分析:达峰时间比与人软骨糖蛋白呈低度负相关(r=-0.278,P=0.001),达峰容积比与人软骨糖蛋白呈低度负相关(r=-0.272,P=0.002)。结论:人软骨糖蛋白可能参与毛细支气管炎的发病,婴儿潮气呼吸肺功能是评价毛细支气管炎患儿病情的客观指标。
OBJECTIVE: To determine the significance of various indexes in bronchiolitis by measuring serum human chondrocytic glycoprotein, tidal volume, peak time ratio and peak volume ratio in children with bronchiolitis. Methods: The serum levels of human chondrocyte glycoprotein in 85 children with bronchiolitis (40 in mild group and 45 in severe group), 44 in children with common pneumonia and 47 in control group were detected for bronchiolitis group and Normal pneumonia group tidal volume, peak time and peak volume ratio, and statistical analysis. Results: Serum human cartilage glycoprotein concentration in bronchiolitis group was higher than that in pneumonia group and control group (P <0.05). There was no significant difference in tidal volume between mild bronchiolitis group, severe bronchiolitis group and ordinary pneumonia group (F = 0.90, P = 0.408). The peak time was significantly higher than that in the three groups (H = 74.844, P <0.001), severe bronchiolitis group was lower than mild bronchiolitis group (χ ~ 2 = 8.78, P <0.05) Bronchitis group was lower than the common pneumonia group (χ ~ 2 = 27.50, P <0.05). (P <0.001). Severe bronchiolitis group was lower than mild bronchiolitis group (χ ~ 2 = 6.80, P <0.05), slightly capillary Bronchitis group was lower than the common pneumonia group (χ ~ 2 = 32.70, P <0.05). Correlation analysis: The peak time was significantly negatively correlated with human cartilage glycoprotein (r = -0.278, P = 0.001), and the peak volume ratio was negatively correlated with human cartilage glycoprotein (r = -0.272, P = 0.002). CONCLUSION: Human cartilage glycoprotein may be involved in the pathogenesis of bronchiolitis. Infantile tidal breathing pulmonary function is an objective indicator to evaluate the condition of children with bronchiolitis.