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目的探讨高级别脑胶质瘤术后放疗联合国产替莫唑胺化疗的临床效果与不良反应。方法选取2008年1月~2012年1月本院收治的高级别脑胶质瘤患者48例,随机平均分为两组,每组24例。术后都给予放疗,实验组在放疗的基础上使用国产替莫唑胺化疗。结果对照组有效率为25%,疾病控制率为54.2%,实验组有效率为62.5%,疾病控制率为91.7%,两组患者有效率之间对比以及疾病控制率之间对比差异有统计学意义(P<0.05),实验组6月生存率为87.5%,1年生存率为62.5%;对照组6月生存率为58.3%,一年生存率为20.8%,差异均有统计学意义(P<0.05)。实验组不良反应稍高于对照组,但差异无统计学意义(P>0.05)。结论高级别脑胶质瘤术后联合放疗和化疗具有协同效应,可以增强疗效,提高患者生存率以及生活质量。
Objective To investigate the clinical effects and adverse reactions of high-grade glioma postoperative radiotherapy combined with temozolomide chemotherapy. Methods Forty-eight patients with high-grade gliomas admitted to our hospital from January 2008 to January 2012 were randomly divided into two groups (24 in each group). Radiotherapy was given after surgery. The experimental group used domestic temozolomide chemotherapy on the basis of radiotherapy. Results The effective rate of the control group was 25%, the disease control rate was 54.2%, the effective rate of the experimental group was 62.5% and the disease control rate was 91.7%. There was statistically significant difference between the two groups in the effective rate and in the disease control rate (P <0.05). The survival rate of the experimental group was 87.5% in June and 62.5% in 1-year. The survival rate of the control group in June was 58.3% and the one-year survival rate was 20.8%, the differences were statistically significant (P < P <0.05). Adverse reactions in the experimental group were slightly higher than those in the control group, but the difference was not statistically significant (P> 0.05). Conclusion High-grade glioma combined with radiotherapy and chemotherapy have a synergistic effect after operation, which can enhance the curative effect and improve the patient’s survival rate and quality of life.