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AIM:To assess the possibility of non-invasive screening ofatrophic chronic gastritis for preventing further developmentof gastric cancer.METHODS:One hundred and seventy-eight consecutiveHelicobacter pylori(H pylori)-positive dyspeptic patientsafter detection of serum levels of pepsinogen-1(PG-1)andgastrin-17(G-17)by enzyme immunoassay were proposedfor endoscopy and histology.The serologic and morphologicresults were compared with estimating the sensitivity,specificity and prognostic values of the tests.RESULTS:There was statistically significant reversedependence between the grade of stomach mucosal antralor corpus atrophy and the proper decreasing of serum G17or PG1 levels.The serologic method was quite sensitive inthe diagnosis of non-atrophic and severe antral and corpusgastritis.Also,it was characterized by the high positive andnegative prognostic values.CONCLUSION:Detection of serum G-17 and PG1 levels canbe offered as the screening tool for atrophic gastritis.Thepositive serologic results require further chromoendoscopywith mucosal biopsy,for revealing probable progressing ofatrophic process with development of intestinal metaplasia,dysplasia or gastric cancer.Pasechnikov VD,Chukov SZ,Kotelevets SM,Mostovov AN,Mernova VP,Polyakova MB.Possibility of non-invasive diagnosisof gastric mucosal precancerous changes.World J Gastroenterol2004;10(21):3146-3150http://www.wjgnet.com/1007-9327/10/3146.asp
AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric cancer. METHODS: One hundred and seventy-eight consecutiveHelicobacter pylori (H pylori) -positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG- 1) and gastrictrin-17 (G-17) by enzyme immunoassay were proposed for endoscopy and histology.The serologic and morphologicresults were compared with the sensitivity, specificity and prognostic values of the tests .RESULTS: There was a significant significant reversedependence between the grade of stomach mucosal antral corpus atrophy and the proper decreasing of serum G17or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpusgastritis. Also, it was characterized by the high positive andnegative prognostic values. CONCLUSION: Detection of serum G-17 and PG1 levels canbe offered as the screening tool for atrophic gastritis.Thepositive serologi c results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with development of intestinal metaplasia, dysplasia or gastric cancer. Pasechnikov VD, Chukov SZ, Kotelevets SM, Mostovov AN, Mernova VP, Polyakova MB. Possibility of non-invasive diagnosis of gastric mucosal precancerous changes. World J Gastroenterol 2004; 10 (21): 3146-3150http: //www.wjgnet.com/1007-9327/10/3146.asp