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目的观察肾炎康颗粒的抗菌抗炎镇痛作用。方法采用抗菌实验观察肾炎康颗粒的抗菌作用;采用小鼠棉球肉芽肿模型和乙酸致小鼠腹腔毛细血管通透性增高模型观察其抗炎作用;采用扭体法和热板法观察其镇痛作用。结果肾炎康颗粒在体外对金黄色葡萄球菌和表皮葡萄球菌有杀菌作用,能提高金黄色葡萄球菌腹腔感染小鼠的存活率,减轻小鼠棉球肉芽组织重量,减轻乙酸所致小鼠腹腔毛细血管通透性增高的炎症反应。同时亦能减少乙酸致小鼠扭体次数,延缓小鼠舔后足的时间。结论肾炎康颗粒具有较好的抗菌抗炎镇痛作用。
Objective To observe the antibacterial, anti-inflammatory and analgesic effects of Shenyankang Granules. Methods Antimicrobial experiments were used to observe the antibacterial effect of Shenyankang granule. The anti-inflammatory effects of glomerulonephritis granuloma model and acetic acid induced peritoneal capillary permeability in mice were observed. The anti-inflammatory effects were observed by using writhing method and hot plate method Pain effect. Results Shenyankang Granules in vitro bacteriostasis of Staphylococcus aureus and Staphylococcus epidermidis, can improve the survival rate of Staphylococcus aureus infection in mice, reduce the weight of cotton granulation tissue, reduce the acetic acid-induced mouse peritoneal capillary Vascular permeability increased inflammatory response. At the same time can also reduce the number of writhing caused by acetic acid in mice, delayed licking the hind foot time. Conclusion Shenyankang granule has good antibacterial, anti-inflammatory and analgesic effects.