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[目的]了解育龄期妇女乙型肝炎病毒(HBV)感染状况。[方法]采用多阶段随机抽样方法,抽取山东省12个县(市、区)20~49岁育龄期妇女1 524人为研究对象,对所有调查对象进行问卷调查和血标本采集检测。[结果]检测1 524人,乙肝病毒表面抗原(HBsAg)阳性率为4.53%,乙肝病毒表面抗体(抗-HBs)阳性率为40.35%,乙肝病毒e抗原(HBeAg)阳性率为1.57%,乙肝病毒e抗体(抗-HBe)阳性率为2.17%。全部调查对象中,HBsAg单阳性的占2.95%,HBsAg、HBeAg双阳性的占1.57%。HBsAg阳性率,东部地区为6.39%,中部地区为2.33%,西部地区为4.57%(P<0.01);城区为6.48%,农村为3.55%(P<0.01)。HBV易感率为51.31%,其中东部地区为45.62%,中部地区为50.53%,西部地区为58.25%(P<0.01);农村为54.68%,城区为44.60%(P<0.01)。调查对象乙肝疫苗全程接种率为10.96%,其中20~29岁为17.82%,30~39岁为11.45%,40~49岁为7.18%(P<0.01);东部地区为15.69%,中部地区为10.36%,西部地区为6.32%(P<0.01);农村为7.29%,城区为18.27%(P<0.01)。[结论]山东省育龄期妇女HBsAg阳性率和HBV易感率较高,乙肝疫苗全程接种率较低。
[Objective] To understand the status of hepatitis B virus (HBV) infection in women of childbearing age. [Methods] A total of 1 524 women of childbearing age from 20 to 49 years of age in 12 counties (cities and districts) of Shandong Province were selected as the research objects by multi-stage random sampling method. All the surveyed subjects were surveyed and blood samples were collected and tested. [Results] The positive rate of hepatitis B virus surface antigen (HBsAg) was 4.53%, the positive rate of HBsAg was 40.35%, the positive rate of HBeAg was 1.57% The positive rate of virus e antibody (anti-HBe) was 2.17%. All surveyed subjects, accounting for 2.95% of single positive HBsAg, HBsAg, HBeAg double positive accounted for 1.57%. The positive rate of HBsAg was 6.39% in the eastern part, 2.33% in the central part and 4.57% in the western part (P <0.01). The urban area was 6.48% and the rural area was 3.55% (P <0.01). The susceptibility rate of HBV was 51.31%, which was 45.62% in the eastern part, 50.53% in the middle part and 58.25% in the western part (P <0.01). In the rural area, it was 54.68% and in the urban area was 44.60% (P <0.01). The whole vaccination rate of Hepatitis B vaccine in the surveyed subjects was 10.96%, of which, 17.82% were from 20 to 29 years old, 11.45% from 30 to 39 years old and 7.18% (P <0.01) from 40 to 49 years old, 15.69% from the eastern region, 10.36% in the western region, 6.32% in the western region (P <0.01); 7.29% in rural areas and 18.27% in urban areas (P <0.01). [Conclusion] The positive rate of HBsAg and the susceptibility of HBV in women of childbearing age in Shandong Province are higher than those in other provinces. The whole vaccination rate of hepatitis B vaccine is low.