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多器官功能障碍综合征(MODS)病死率高达50％~90％,一般认为MODS是进入ICU的患者发病和病死的首要原因,但其发病机制迄今尚未阐明,感染特别是脂多糖及内毒素被认为是全身炎症反应综合征和MODS的主要启动因子。经多年的研究与探索,形成了从最早的器官缺血-再灌注损伤及感染学说到肠源性感染、微循环和全身炎症反应失控学说,还有学者提出细胞凋亡学说和非线性系统学说。这些理论的形成与血管内皮系统的结构、功能及其调节有密切关系,本文对在MODS过程中内皮细胞(EC)在凝血过程中的生理作用,EC受损与MODS凝血-抗凝血机制紊乱作一综述。
Multiple organ dysfunction syndrome (MODS) mortality of up to 50% to 90%, is generally believed that MODS is the leading cause of morbidity and mortality in patients admitted to the ICU, but its pathogenesis has not yet been clarified, the infection, especially lipopolysaccharide and endotoxin was It is thought to be a major promoter of systemic inflammatory response syndrome and MODS. After many years of research and exploration, from the earliest organ ischemia-reperfusion injury and infection theory to enterogenous infection, microcirculation and systemic inflammatory response out of control theory, there are scholars put forward the theory of apoptosis and nonlinear system theory . The formation of these theories is closely related to the structure, function and regulation of vascular endothelium system. In this paper, the physiological roles of endothelial cells (ECs) during coagulation, the impaired EC and the coagulation-anticoagulant mechanism of MODS in MODS Make a review