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目的:筛选在气血相生理论指导下,由临床验方化裁的7种方剂中,益气补血作用最显著的方剂。方法:采用环磷酰胺(CY)腹腔注射致ICR小鼠红白减少症模型,连续给药15 d,对ICR小鼠外周血中的红白细胞数量和T细胞亚群CD2、CD3、CD4等指标进行检测。结果:在临床验方中的7种方剂中,各组小鼠检测指标与模型组相比,差异显著P<0.05或P<0.01,其中益气方组在RBC、WBC、Hb和CD2、CD3、CD4的检测结果中差异最为显著(P<0.01)。结论:益气方对于提升化疗后小鼠的红白细胞数量,改善化疗后的免疫力有重要作用。
OBJECTIVE: To screen out the seven prescriptions which are curative effect of qi and blood supplement under the guidance of qi and blood stasis theory. Methods: ICR mice were induced by intraperitoneal injection of cyclophosphamide (CY) for 15 days. The numbers of erythroblasts and CD2, CD3 and CD4 in peripheral blood of ICR mice Test. Results: Among the seven prescriptions of clinical prescriptions, the detection indexes of mice in each group were significantly different from those in model group (P <0.05 or P <0.01) The difference between CD4 test results was the most significant (P <0.01). Conclusion: Yiqi prescription can improve the number of red and white cells in mice after chemotherapy and improve the immunity after chemotherapy.