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自1971年Fischer提出“伪神经递质学说”以来,有关慢性肝病,肝功能不全对氨基酸代谢的影响日益引起重视。1975年Fischer等又发现在慢性肝功能不全或肝性脑病患者,存在着某些氨基酸比率的改变,主要是缬氨酸、亮氨酸、异亮氨酸三种支链氨基酸的降低和苯丙氨酸、酪氨酸等芳香族氨基酸的增高,后者可高达正常的3倍,而色氨酸轻度增高。他在正常人和犬的实验中观察到,(缬+亮+异亮)/(苯丙+酪)(简称支/芳比)的平
Since 1971, Fischer proposed “pseudo-neurotransmitter theory ”, the impact of chronic liver disease, liver dysfunction on amino acid metabolism has drawn increasing attention. In 1975 Fischer et al found that in patients with chronic hepatic insufficiency or hepatic encephalopathy, there are some changes in the ratio of amino acids, mainly valine, leucine, isoleucine three branched-chain amino acids decreased and phenylpropanoid Amino acids, tyrosine and other aromatic amino acids increased, the latter up to 3 times the normal, and slightly elevated tryptophan. He observed in normal and canine experiments, (Valerian light + isolute) / (phenylpropyl + cheese) (referred to as branch / aromatic ratio) of flat