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布洛芬(Ibuprofen)化学名称为2-(对异丁苯基)丙酸,是一种非甾体消炎镇痛药物,其作用强而副作用小,在治疗风湿性关节炎等疾病方面获得了较好声誉。布洛芬的合成方法甚多,若以异丁苯为起始原料,通过典型的 Friedel-Crafts 及 Darzens 反应(α,β-epoxyester)得到中间体(2)后,均经氧化制得布洛芬。氧化方法较多,归纳文献有高锰酸钾或氧化银法,重铬酸法,过氧化氢法及金属催化光化学氧化法等。我们认为合成布洛芬,较佳的氧化方法是次氯酸钠低温氧化及氧气金属盐催化自动氧化,次氯酸钠低温氧化将另文研
Ibuprofen Chemical Name 2- (p-isobutylphenyl) propionic acid, is a non-steroidal anti-inflammatory analgesic drug, its strong role and side effects, in the treatment of rheumatoid arthritis and other diseases have been Better reputation. Ibuprofen has many synthetic methods. If isobutylbenzene is used as a starting material, the intermediate (2) is obtained through typical Friedel-Crafts and Darzens reaction (α, β-epoxyester) Fen. There are many oxidation methods, inducing potassium permanganate or silver oxide, dichromate, hydrogen peroxide and metal catalytic photochemical oxidation. We believe that the synthesis of ibuprofen, the better oxidation method is hypochlorite low temperature oxidation and oxygen metal salt catalytic auto-oxidation, hypochlorite low temperature oxidation will be another research