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本文报告了新疆饮水含砷量在0.185～0.85mg/L的某地区居民中的523例慢性地方性砷中毒的临床表现。大部分病人具有砷性皮肤体征,即砷性角化占85.5%,砷性脱色斑占58.5％,灰褐色色素沉着占39.8％。病人头发、尿、指甲含砷高,其中测定的43例发砷值为0.455±0.305mg/100g,对照组15例为0.065±0.071mg/100g;109例尿砷为0.297±0.344mg/L,对照23例为0.061±0.034mg/L;13例指甲砷为18.9±22.0μg/g。讨论了慢性地方性砷中毒的病理表现,由于砷中毒有恶性倾向,必须仔细监视皮肤癌的发生。作者们认为皮肤病变是慢性地方性砷中毒的特异改变,可以作为它的主要临床诊断指征。
This article reports the clinical manifestations of 523 chronic endemic arsenisms among residents in a drinking water containing arsenic from 0.185 to 0.85 mg / L in Xinjiang. Most patients have signs of arsenic skin, that is, 85.5% of arsenic keratosis, 58.5% of arsenic spots, taupe pigmentation of 39.8%. Patients with hair, urine, nails containing arsenic high, of which measured 43 cases of arsenic was 0.455 ± 0.305mg / 100g, 15 cases of control group was 0.065 ± 0.071mg / 100g; 109 cases of urinary arsenic was 0.297 ± 0.344mg / L, The control group was 0.061 ± 0.034 mg / L in 23 cases and 18.9 ± 22.0 μg / g in 13 cases. Discussed the chronic local arsenic poisoning pathology, due to the malignant tendency of arsenic poisoning, we must carefully monitor the occurrence of skin cancer. The authors believe that skin lesions are specific changes in chronic endemic arsenic poisoning and can be used as an indication of its main clinical diagnosis.