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目的：研究氟康唑滴眼液（ｆｌｕｃｏｎａｚｏｌｅｅｙｅｄｒｏｐｓ，ＦＣＺＥＤ）对兔眼实验性烟曲霉菌角膜溃疡的治疗作用。方法：测定ＦＣＺＥＤ对烟曲霉菌的最小抑菌浓度（ＭＩＣ）。取１０５ｃｆｕ·ｍｌ－１烟曲霉菌悬液２０μｌ，接种于兔眼角膜实质层，２４ｈ后随机分为４组，２，５ｇ·Ｌ－１ＦＣＺＥＤ；氟康唑静脉注射（ＦＣＺｉｖ）；生理氯化钠溶液对照，同时进行治疗。治疗结束，每组取４眼角膜，按霉菌总数平板测定法，计测菌落数。结果：ＦＣＺＥＤ对烟曲霉菌的ＭＩＣ值为０．１２５～０．２５ｇ·Ｌ－１。５ｇ·Ｌ－１ＦＣＺＥＤ治疗烟曲霉菌角膜溃疡与对照相比有显著疗效（Ｐ＜０．０１）。霉菌培养结果，５ｇ·Ｌ－１ＦＣＺＥＤ与对照组相比霉菌计数明显减少（Ｐ＜０．０１）。结论：５ｇ·Ｌ－１ＦＣＺＥＤ治疗实验性烟曲霉菌角膜溃疡有效。
Objective: To study the therapeutic effect of fluconazoleeyroprops (FCZED) on experimental Aspergillus fumigatus corneal ulcer in rabbit eyes. Methods: The minimum inhibitory concentration (MIC) of FCZED against Aspergillus fumigatus was determined. Twenty microliters of 105cfu ml-1 Aspergillus fumigatus suspension were inoculated into the cornea of rabbit cornea and were randomly divided into 4 groups (2,5 gL-1 FCZED), intravenous injection of fluconazole (FCZiv), physiological sodium chloride Solution control, at the same time for treatment. At the end of treatment, 4 corneas were taken in each group, and the number of colonies was counted according to the total number of molds. Results: The MIC of FCZED against Aspergillus fumigatus was 0.125-0.25g · L-1.5g · L-1FCZED. The treatment of Aspergillus fumigatus corneal ulcer had a significant effect (P <0.01) compared with the control. Mold culture results, 5g · L-1FCZED compared with the control group mold count was significantly reduced (P <0.01). Conclusion: 5g · L-1FCZED treatment of experimental Aspergillus fumigatus corneal ulcer effective.