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目的探讨米非司酮配伍不同剂量米索前列醇终止中期妊娠的效果。方法选择本院2010年1月～2011年3月中期妊娠引产的孕妇123例,应用米非司酮配伍米索前列醇终止妊娠。根据米索前列醇的用量分为3组:其中应用米索前列醇25μg(A组)41例、米索前列醇50μg(B组)41例、米索前列醇75μg(C组)41例。早晨口服米非司酮150mg,取米索前列醇25μg、50μg、75μg分别放入A组、B组、C组产妇后穹隆,观察产妇宫缩情况。结果 A组41例,成功35例,占85.4%;有效3例,占7.3%;无效3例,占7.3%;总有效率为92.7%;B组41例,成功36例,占87.8%,有效3例,占7.3%;无效2例,占4.9%;总有效率为95.1%;C组41例,成功37例,占90.2%;有效2例,占4.9%;无效2例,占4.9%;总有效率为95.1%。3组总有效率比较差异无统计学意义(P>0.05)。3组产妇使用米非司酮配伍米索前列醇药后宫缩发动、产程阴道出血情况比较差异均有统计学意义(P<0.05)。用药剂量越大副反应越多。结论小剂量米索前列醇应用于中期妊娠引产是有效、安全的。
Objective To investigate the effect of mifepristone combined with different doses of misoprostol to terminate the second trimester pregnancy. Methods 123 cases of pregnant women who induced labor during midterm gestation from January 2010 to March 2011 were selected and terminated by mifepristone and misoprostol. According to the amount of misoprostol divided into 3 groups: 41 cases were treated with misoprostol 25μg (group A), 41 cases with misoprostol 50μg (group B) and 41μg misoprostol (group C). Morning oral mifepristone 150mg, take misoprostol 25μg, 50μg, 75μg were placed in group A, B, C group maternal vault, observed maternal contractions. Results A group of 41 cases, 35 cases were successful, accounting for 85.4%; 3 cases were effective, accounting for 7.3%; 3 cases were ineffective, accounting for 7.3%; the total effective rate was 92.7%; B group 41 cases, 36 cases successful, accounting for 87.8% 3 cases were effective, accounting for 7.3%; 2 cases were ineffective, accounting for 4.9%; the total effective rate was 95.1%; 41 cases were successful in C group, 37 cases were successful, accounting for 90.2%; 2 cases were effective, 4.9% %; The total effective rate was 95.1%. There was no significant difference in total effective rate between the three groups (P> 0.05). Three groups of maternal use of mifepristone combined with misoprostol medicine after uterine contractions, vaginal bleeding during labor were significantly different (P <0.05). The larger the dose the more side reactions. Conclusion The application of low-dose misoprostol in induction of labor during mid-term pregnancy is effective and safe.