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中枢神经系统具有血脑屏障、缺乏淋巴引流系统和抗原提呈细胞而被称为“免疫特免区”，在组织移植过程中具有与周围器官不同的特点。越来越多的研究发现脑作为免疫部位又有局限性，脑内的小胶质细胞和星形胶质细胞在组织移植的过程中可增生活化、表达ＭＨＣⅡ类抗原，最后引起免疫排斥反应。本文综述了中枢神经系统在免疫学方面的新发现，以及与组织移植的关系
Central nervous system has a blood-brain barrier, the lack of lymphatic drainage system and antigen-presenting cells and is called “immunocompetent region”, in the process of tissue transplantation and the surrounding organs have different characteristics. More and more studies have found that the brain has some limitations as an immunological site. Microglial cells and astrocytes in the brain can proliferate and activate during tissue transplantation to express MHC class II antigens and eventually cause immune rejection . This article reviews the recent findings in immunology of the central nervous system and its relationship to tissue transplantation