论文部分内容阅读
目的:探讨新辅助化疗前后同一大肠癌患者微血管密度(MVD)有否变化及其与预后的关系。方法:选择确诊为大肠癌的患者28例为观察组,分别检测同一患者经动脉新辅助化疗前后MVD。同期设未行治疗的大肠癌患者25例为对照组。结果:观察组患者MVD有明显变化,统计学检验P<0.05,有显著性差异。对照组患者其MVD无明显变化。新辅助化疗后患者3年内复发6例,对照组3年内复发13例。复发者其MVD明显高于未复发者,经统计学检验P<0.05,有显著性差异。结论:新辅助化疗前后同一大肠癌患者MVD有明显变化.提示新辅助化疗可以降低MVD;新辅助化疗后患者3年内复发率明显低于未行术前化疗的同期大肠癌患者。提示新辅助化疗后降低肿瘤患者术后复发率与MVD减少有关,对于估计肿瘤患者的预后及指导临床治疗具有重要意义。
Objective: To investigate the changes of microvessel density (MVD) in patients with the same colorectal cancer before and after neoadjuvant chemotherapy and its relationship with prognosis. Methods: Twenty-eight patients diagnosed as colorectal cancer were selected as the observation group, and the MVD of the same patient before and after the new adjuvant chemotherapy was detected. In the same period, 25 patients with colorectal cancer who did not receive treatment were selected as the control group. Results: The MVD in the observation group changed significantly. Statistical test P <0.05 showed significant difference. MVD in control group did not change significantly. After neoadjuvant chemotherapy in 6 patients relapsed within 6 years, control group relapsed in 13 cases within 3 years. MVD was significantly higher in relapsed patients than in those who did not relapse, the statistical test P <0.05, significant difference. Conclusions: The MVD in patients with the same colorectal cancer before and after neoadjuvant chemotherapy significantly changes, suggesting that neoadjuvant chemotherapy can reduce MVD. The recurrence rate of neoadjuvant chemotherapy patients after 3 years is obviously lower than that of patients without concomitant chemotherapy. Prompted neoadjuvant chemotherapy to reduce the recurrence rate of tumor patients with MVD decreased, for the estimation of prognosis of cancer patients and to guide the clinical treatment of great significance.