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目的:研究类风湿关节炎患者滑膜组织中色素上皮衍生因子(Piment epithelial-derived factor,PEDF)的表达情况。方法:采用免疫组化法,检测30例类风湿关节炎活动期膝关节滑膜组织中PEDF蛋白表达,以16例退行性关节炎患者、16例正常人及该30例患者治疗后(稳定期)关节滑膜组织中PEDF蛋白作对照,进行对比分析。结果:PEDF在类风湿关节炎患者明显低于正常人、退行性关节炎患者滑膜组织中的表达,在活动期滑膜组织中的表达明显低于稳定期,组间比较,差异均有统计学意义(P均<0.05)。结论:PEDF与类风湿关节炎的疾病过程密切相关,针对色素上皮衍生因子的靶点治疗有望成为类风湿关节炎治疗的新的方向及策略。
Objective: To investigate the expression of PEDF in synovial tissue from rheumatoid arthritis patients. Methods: Immunohistochemical method was used to detect the expression of PEDF protein in 30 cases of rheumatoid arthritis synovial tissue during the active stage. After treatment with 16 cases of degenerative arthritis, 16 cases of normal and 30 cases of patients (stable stage ) Synovial tissue PEDF protein as a control, for comparative analysis. Results: The expression of PEDF in patients with rheumatoid arthritis was significantly lower than that in normal people and patients with degenerative arthritis, and the expression of PEDF in active synovium was significantly lower than that in stable phase Significance (P <0.05). Conclusion: PEDF is closely related to the disease process of rheumatoid arthritis. Target therapy of pigment epithelium-derived factor is expected to become a new direction and strategy for the treatment of rheumatoid arthritis.