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以四川抗菌素工业研究所研制的云芝胞内多糖治疗慢性乙型肝炎240例,进行了疗效、免疫功能及毒副作用观察。在能评定出疗效的216例(慢性迁延性肝炎132例,慢性活动性肝炎84例)中,近期控制21例(9.7％),显效64例(29.6％),好转74例(34.3％),无效57例(26.4％)。显效以上85例(39.4％),总有效率为73.6％。在163例的对比观察病例中,治后HBsAg转阴39例(23.9％),滴度下降54例(33.1％)。治疗前后作免疫复合物检测82例,治后免疫复合物呈阴性者,不论慢性迁延性肝炎或慢性活动性肝炎均较治前增多,尤以慢性迁延性肝炎者增多有极显著性差异(P<0.01)。治疗前后测PHA皮试83例,治后反应有极显著性增进(P<0.01)。本组病例治疗期中未见毒副作用。因此,提示云芝胞内多糖治疗慢性乙型肝炎安全、有效,能增强免疫,对清除或降低HBsAg滴度可能有一定作用。
240 cases of Chronic Hepatitis B were treated with polysaccharide of Coriolus versicolor from Sichuan Institute of Antibiotics. The curative effect, immune function and side effects were observed. Of 216 patients (132 with chronic persistent hepatitis and 84 with chronic active hepatitis) who were assessed for efficacy, 21 (9.7%) were significantly controlled, 64 (29.6%) were significantly improved, 74 (34.3%) were improved, Invalid 57 cases (26.4%). 85 cases markedly effective (39.4%), the total effective rate was 73.6%. Among 163 cases of contrast observation, 39 cases (23.9%) were HBsAg negative after treatment and 54 cases (33.1%) had decreased titer. Before and after treatment for immune complex test of 82 cases, the immune complex after treatment was negative, regardless of chronic persistent hepatitis or chronic active hepatitis increased compared with pre-treatment, especially in patients with chronic persistent hepatitis increased significantly (P <0.01). 83 cases of PHA skin test before and after treatment, post-treatment response was significantly improved (P <0.01). The treatment of this group no toxic side effects. Therefore, suggesting that intracellular polysaccharide of Coriolus versicolor treatment of chronic hepatitis B is safe, effective, can enhance immunity, may have some effect on clearing or reducing HBsAg titer.