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本文报道我院1979～1984年所见6例抗惊厥药物所引起的骨软化症(4例癫痫、2例精神分裂症患者)。6例中女5男1,骨病病程最短者1年,最长者6年。服抗惊厥药物最短者6年,最长者12年。所服药物:苯妥英钠5例,冬眠灵2例,并服奋乃静2例,安坦1例。药物剂量:苯妥英钠0.2～0.3g/日,冬眠灵200～400mg/日,奋乃静20mg/日,安坦6mg/日。本症临床症状、体征、生化及骨骼X线改变与缺乏维生素D所致骨软化症相似。
This article reports on our hospital from 1979 to 1984, six cases of seizures caused by osteomalacia drugs (4 cases of epilepsy, 2 cases of schizophrenia). 6 cases of female 5 male 1, the shortest duration of bone disease 1 year, the longest 6 years. Anticonvulsant drug service for the shortest of 6 years, the longest 12 years. The medication: phenytoin in 5 cases, 2 cases of winter sleep Ling, and service perphenazine in 2 cases, 1 case of An Tan. Drug dose: phenytoin 0.2 ~ 0.3g / day, winter sleep Ling 200 ~ 400mg / day, perphenazine 20mg / day, An Tan 6mg / day. Symptoms, signs, biochemical and skeletal X-ray changes and lack of vitamin D-induced osteomalacia similar.