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本文采用放射免疫法分别检测了21例正常儿和46例婴幼儿肺炎患者血浆内皮素浓度,其中轻型16例,重症肺炎(不含心衰)11例,毛细支气管炎9例,肺炎心衰患者10例。结果显示:轻型肺炎组患者血浆内皮素浓度为36.49±14.08pg/ml,与正常对照组34.41±14.38pg/ml,无显著差异(P>0.05);重症肺炎组患者血浆内皮素浓度49.73±15.49pg/ml较正常对照组增高(P<0.01);毛细支气管炎和肺炎心衰组患者血浆内皮素浓度分别为74.03±24.50pg/ml和76.76±24.54pg/ml,明显高于正常对照组(P<0.01),且两组患者较重症肺炎增高更为显著(P<0.01),提示血浆内皮素浓度与婴幼儿肺炎轻重程度成正比,内皮素参于了重症肺炎病理生理发病过程,它可能是导致心力衰竭重要因素之一。
In this paper, radioimmunoassay were detected in 21 cases of normal children and 46 cases of infantile pneumonia in patients with plasma endothelin concentrations, including 16 cases of light, severe pneumonia (without heart failure) in 11 cases, bronchiolitis in 9 cases, patients with heart failure of pneumonia 10 cases. The results showed that the plasma endothelin concentration in patients with mild pneumonia was 36.49 ± 14.08 pg / ml, which was significantly higher than that in normal controls (34.41 ± 14.38pg / ml, P> 0.05). The plasma endothelin concentration in patients with severe pneumonia was 49.73 ± 15.49 pg / ml was higher than that of the normal control group (P <0.01). The concentrations of endothelin in patients with bronchiolitis and heart failure were 74.03 ± 24.50pg / ml and 76.76 ± 24.54pg / ml, respectively, which were significantly higher than those in the normal control group P <0.01), and the two groups of patients with severe pneumonia increased more significantly (P <0.01), suggesting that plasma endothelin concentration is proportional to the severity of pneumonia in infants and young children, endothelin is involved in the pathophysiology of severe pneumonia pathogenesis, it may Is one of the important factors leading to heart failure.