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１９８９～１９９１年在河北省发生了脊髓灰质炎Ⅰ型自然重组株病毒的流行（为脊髓灰质炎野病毒和疫苗病毒的基因重组），对重组病毒麻痹病例进行了调查，已发现的病例分布在河北省的六个市地，占省辖市地数的５０％，病例全部为４岁以下农村儿童，发病时间以四月为高峰，８５％病例为没有接种或没有全程接种脊髓灰质炎疫苗，病例的临床症状主要是发热、腹泄、肢体麻痹，严重病例可发生呼吸困难。但有半数病例在６０天肢体麻痹恢复。
From 1989 to 1991, a poliovirus type I natural recombinant strain (poliovirus and vaccine virus gene recombination) occurred in Hebei Province. The cases of recombinant virus paralysis were investigated. The detected cases were found in Six cities in Hebei Province accounted for 50% of the total number of provincial cities. All cases were rural children under 4 years old. The onset time peaked at April, 85% of cases were not vaccinated or did not receive full polio vaccine, Clinical symptoms of the case are mainly fever, diarrhea, limb paralysis, severe cases of dyspnea can occur. However, in half of the cases, limb paralysis recovered on the 60th day.