【摘 要】
：
Pregnancies achieved by assisted reproduction technologies,particularly by intracytoplasmic sperm injection(ICSI)procedures,are susceptible to genetic risks in
【出 处】
：
Asian Journal of Andrology
论文部分内容阅读
Pregnancies achieved by assisted reproduction technologies,particularly by intracytoplasmic sperm injection(ICSI)procedures,are susceptible to genetic risks inherent to the male population treated with ICSI and additionalrisks inherent to this innovative procedure.The documented,as well as the theoretical,risks are discussed in thepresent review study.These risks mainly represent thatconsequences of the genetic abnormalities underlying malesubfertility(or infertility)and might become stimulators for the development of novel approaches and applications inthe treatment of infertility.In addition,risks with a polygenic background appearing at birth as congenital anomaliesand other theoretical or stochastic risks are discussed.Recent data suggest that assisted reproductive technologymight also affect epigenetic characteristics of the male gamete,the female gamete,or might have an impact on earlyembryogenesis.It might be also associated with an increased risk for genomic imprinting abnormalities.(Asian JAndrol 2006 Nov;8:643-673)
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