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Hepatic hydrothorax occurs in 4–12% of patients with liver cirrhosis.[1] A part of patients with persisted hydrothorax resists conservative treatment, known as refractory hepatic hydrothorax (RHH). Portal vein thrombosis (PVT) is observed in about 2.1–16.2% patients with liver cirrhosis,[2] which may aggravate portal hypertension. If RHH and PVT are combined in a cirrhotic patient, transjugular intrahepatic portosystemic shunt (TIPS) may be a reasonable intervention.[3] However, no such successful case has been reported. We herein reported a case of cirrhotic patient complicated with both RHH and PVT, who underwent TIPS and achieved long?term survival.