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1978年Mindem首先对急性非淋巴细胞白血病骨髓细胞进行了集落培养,发现了急性白血病集落(leukemic blast Colony forming unic L-CFU)以来,更多的实验证明急性白血病存在着白血病干细胞,它是一组基因发生异常突变来的克隆。经采用染色体检查发现L-CFU核型与培养前白血病细胞相同,1976年FAB分类法发表以来已经
In 1978, Mindem first carried out colony culture of acute non-lymphocytic leukemia bone marrow cells. Since the discovery of leukemic blast colony forming unic L-CFU, more experiments have proved that leukemia stem cells exist in acute leukemia, which is a group Gene mutation to the clones. Chromosome examination revealed that the karyotype of L-CFU was the same as the pre-culture leukemia cells. Since the FAB classification was published in 1976,