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目的 通过观察铅作业女工子女（６ ～１０ 岁） 及１∶１ 对照组血铅、发铅、神经行为及生化的差异，了解铅对神经行为的影响及其生物学基础。方法 采用ＷＨＯ 推荐的神经行为测试组合中适宜儿童的四项测定神经行为功能，采用高效液相色谱法－ 电化学法联检测定尿中高香草酸（ＨＶＡ） 和香草扁桃酸（ＶＡＭ） 的浓度。所得资料用ＳＰＳＳ 软件进行配对ｔ 检验。结果 接触组尿液中ＨＶＡ 和ＶＭＡ 减少（ Ｐ＜０－００１） ，数字广度及最快反应时间得分减少（ Ｐ＜ ０－００１） 。结论 铅对女工子代的ＨＶＡ、ＶＭＡ、数字广度及最快反应时等神经行为生化指标有影响。
Objective To observe the effects of lead on neurobehavioral and its biological basis by observing the differences of blood lead, lead, neurobehavioral and biochemical in female lead children (6 ~ 10 years old) and 1: 1 control group. Methods The neurobehavioral function of four suitable children in the neurobehavioral test combination recommended by the WHO was used to determine the concentrations of HVA and VAM in urine by high performance liquid chromatography coupled with electrochemical detection. The data obtained using SPSS software paired t test. Results There was a decrease in HVA and VMA (P <0-001) in the urine of the exposed group with a decrease in the digital breadth and the fastest response time (P <0-001). Conclusion Lead affects the neurobehavioral and biochemical indexes such as HVA, VMA, digital breadth and the fastest response of female workers.