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双水相萃取技术具有操作条件温和、处理量大、易于连续操作等优点,在生物制药中得到广泛的应用。论文介绍了双水相萃取技术及特点,综述了双水相体系在生物制药方面的应用,展望了双水相体系的应用前景。目前要解决的问题主要集中在新型双水相体系开发、双水相萃取技术的集成与耦合、成相聚合物的回收、热力学模型的完善等方面。
The aqueous two-phase extraction technology has the advantages of mild operating conditions, large processing capacity and easy continuous operation, and is widely used in biopharmaceuticals. In this paper, the technology and characteristics of aqueous two-phase extraction are introduced. The application of bi-aqueous system in biopharmaceutical industry is reviewed. The application prospect of bi-aqueous system is also prospected. At present, the problems to be solved mainly focus on the development of a new type of aqueous two-phase system, the integration and coupling of the aqueous two-phase extraction technology, the recovery of the phase-in polymer and the improvement of the thermodynamic model.