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目的 探讨经鼻持续气道正压通气(NCPAP)对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者糖脂代谢和hs-CRP、S100A12水平的影响.方法 选取40例OSAHS患者为研究对象行前瞻性研究,采用抛硬币方法将40例患者随机分为对照组和观察组,每组20例,分别予以常规保守治疗和NCPAP治疗,疗程均为3个月.治疗前后,检测各组血糖、血脂水平,hs-CRP、S100A12水平.结果 与治疗前比较,治疗后两组患者① TC、TG、LDL-C水平均显著降低,而HDL-C水平显著升高,差异均有统计学意义(P<0.05).观察组患者TC、TG、LDL-C水平明显低于对照组,而HDL-C水平明显高于对照组,差异均有统计学意义(P<0.05);② FBG和2 h PBG水平显著降低,差异均有统计学意义(P<0.05).观察组患者FBG和2 h PBG水平明显低于对照组,差异均有统计学意义(P<0.05);③ hs-CRP、S100A12水平均显著降低,差异均有统计学意义(P<0.05).观察组患者hs-CRP、S100A12水平明显低于对照组,差异均有统计学意义(P<0.05).结论 经鼻持续气道正压通气能够显著调节OSAHS患者糖脂代谢,降低hs-CRP、S100A12水平,从而减少OSAHS患者心血管疾病并发症,改善预后.“,”Objective To investigate the effects of nasal continuous positive airway pressure (NCPAP) on the levels of glucose and lipid metabolism, hs-CRP and S100A12 in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Forty OSAHS patients were selected for prospective study, and randomly divided into a control group (receiving routine conservative treatment) and an experimental group (receiving NCPAP treatment) by the coin-tossing method, with each group containing 20 patients. The treatment continued for 3 months. Before and after treatment, the levels of blood glucose, blood lipid, hs-CRP and S100A12 were analyzed. Results In both groups, the levels of total cholesterol (TC), triglyceride (TG) and LDL cholesterol were significantly decreased after treatment, while the levels of HDL cholesterol were significantly increased (all P<0.05). ① The levels of TC, TG and LDL-C in the experimental group were significantly lower than those in the control group, while the levels of HDL-C in the experimental group were significantly higher than those in the control group (P<0.05). ② Fasting blood glucose (FBG) and 2 h postprandial blood glucose (PBG) levels were significantly decreased after treatment (P<0.05). The levels of FBG and 2 h PBG were significantly lower in the observation group than in the control group (P<0.05). ③ hs-CRP and S100A12 levels were significantly decreased after treatment (P<0.05). The levels of hs-CRP and S100A12 in the experimental group were significantly lower than in the control group (P<0.05). Conclusion Nasal continuous positive airway pressure can significantly regulate blood glucose and lipid metabolism and reduce hs-CRP and S100A12 levels in patients with OSAHS, thereby reducing the cardiovascular complications of OSAHS patients and improving their prognosis.