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目的探讨血清胱抑素C水平对小儿紫癜性肾炎的临床意义。方法选择2013年10月-2015年2月在本院门诊及住院确诊为紫癜性肾炎患儿52例作为观察组,以同期健康体检儿童50例为对照组。比较分析2组血清胱抑素C水平及血清中免疫球蛋白Ig A、Ig G、Ig M与肾功能相关指标。结果观察组患儿Cys-C、Ig A、BUN、Cr水平较对照组均增高,差异有统计学意义(t值分别为6.546、4.332、17.541、19.834,P<0.05);观察组患儿不同病期血清中Cys-C、Ig A、BUN和Cr的含量呈递增趋势,血清Cys-C的相关性较其他项目更好。结论 Cys-C检测对早期发现肾损伤,提高治疗效果与预后具有重要的临床意义。
Objective To investigate the clinical significance of serum cystatin C in purpura nephritis in children. Methods From October 2013 to February 2015, 52 children with purpura nephritis clinically diagnosed and hospitalized in our hospital were selected as the observation group and 50 healthy children in the same period as the control group. The levels of serum cystatin C, serum immunoglobulin Ig A, Ig G, Ig M and renal related indexes were compared and analyzed. Results The levels of Cys-C, Ig A, BUN and Cr in the observation group were significantly higher than those in the control group (t = 6.546, 4.332, 17.541 and 19.834, respectively; P < Serum levels of Cys-C, Ig A, BUN and Cr showed a trend of increasing, serum Cys-C correlation was better than other items. Conclusion The detection of Cys-C has important clinical significance in early detection of renal injury and improvement of therapeutic effect and prognosis.