论文部分内容阅读
乙型肝炎病毒在一定的选择压力下,由于其具有的一些特征,导致比其他DNA病毒更易出现变异。前C区和基本核心启动子(BCP)的变异可产生HBeAg阴性变异株;前S/S区的基因变异可导致HBsAg的漏检;BCP突变和前S缺失突变可增加肝细胞癌的发生概率;P基因变异主要见于耐药性突变;X基因的变异与肝脏癌变形成相关。对于突变株的检测应采用一定的选择策略。
Hepatitis B virus under a certain selection pressure, due to some of its characteristics, leading to more prone to mutation than other DNA viruses. Pre-C and basic core promoter (BCP) mutations can produce HBeAg-negative mutant; S / S gene mutation can lead to HBsAg missed; BCP mutations and pre-S deletion mutations can increase the probability of occurrence of hepatocellular carcinoma ; P gene mutation mainly found in resistance mutations; X gene mutation and liver cancer related to the formation. For the detection of mutant strains should adopt a certain selection strategy.